While cognitive decline and diminishing brain function may or may not
be inevitable as we age, there are fortunately many lifestyle choices
we can make that translate not only to healthier brains but also brains
that may be better able to heal from damage caused by brain trauma and
injury.
For instance, evidence is overwhelming regarding exercise’s ability to increase brain neuroplasticity and offset cognitive impairment
in aging populations. The same can be said of diets that emphasize
fresh vegetables and fruits, with some plant derived compounds
demonstrating specific brain protective properties.
Among the various aspects of the pathophysiological cascade of post
traumatic brain injury, magnesium depletion “ …has been correlated with post-injury neurologic deficits, and pretreatment to restore magnesium levels results in improved motor performance in experimental animals.”
Functionally, magnesium plays a vital role in nerve transmission,
neuroplasticity and cognitive performance. As we age, brain levels of
magnesium decline, exacerbating the erosion of synaptic function in the hippocampus region of the brain, for instance, which has a primary role in the formation of memories.
A unique and highly effective form of magnesium
Magnesium repletion then, especially as we age, is of vital importance.
Unfortunately, magnesium from both food and supplementation has not
been proven to elevate brain magnesium levels adequately enough to
produce a therapeutic effect. One form of magnesium though, magnesium threonate, has been found to significantly increase brain levels of magnesium leading to improvements in synaptic plasticity, memory, cognition and learning.
The disruptive power of oxidative stress
The pathophysiological cascade of events that occur immediately
following traumatic brain injury (TBI) include the creation of high
levels of cell membrane damaging oxidative stress.
Beyond cell membrane damaging lipid peroxidative action, oxidative
stress “can cause a number of deleterious effects in cells including
inhibition of DNA synthesis, disturbance in calcium homeostasis, and
inhibition of mitochondrial respiration.” Cell membrane disruption
together with subsequent pathophysiological events will cause cognitive
deficits that may manifest themselves as learning difficulties, memory
loss and decreased synaptic plasticity.
The benefits of curcumin
Cerebral edema is another common consequence of TBI. Dietary polyphenols like curcumin, the polyphenol found in turmeric, has been shown to have utility
in brain disease, injury and cognitive function. Curcumin’s powerful
antioxidative properties has been shown to be effective in
neurodegenerative conditions such as Alzheimer’s disease and was shown
to attenuate the severity of edema and hematoma in animal models of brain injury. In the preceding study, supplemental curcumin was also shown to improve brain cell membrane homeostasis and stability, neuronal signaling and cognitive deficits in animal models of traumatic brain injury.
Neurodegenerative diseases have a similar albeit slower progression
of events including excitotoxicity, leading to neuronal cell death.
Excitotoxicity is a pathological process by which neurons are damaged
and killed by the over activation of receptors for the excitatory
neurotransmitter glutamate. This leads to the activation of a number of
enzymes, which go on to damage cell structures such as components of the
cell membrane and DNA. Excitotoxicity is involved in not only stroke
and traumatic brain injury, but also neurodegenerative diseases of the
central nervous system such as Multiple Sclerosis, Alzheimer's disease,
Amyotrophic Lateral Sclerosis, Parkinson's disease, and Huntington's
disease.
Green tea and brain health
Green tea consumption, with its plentiful concentration of polyphenols or more specifically, its green tea catechins, like curcumin, possesses brain protective properties
which include its ability to increase neuronal viability, improve
mitochondrial function and act as a powerful antioxidant. Iron in excess
can be powerfully oxidative and has been shown to accumulate in
specific parts of the brain like the hippocampus, again a vital center
of cognition and memory formation. Green tea has iron chelation
abilities that may offer addition brain protection and disease
protection.
Finally, polyphenols from grape extracts were shown to decrease DNA damage in animal models of ischemic brain injury.
These examples just scratch the surface of the plethora of lifestyle,
dietary and nutritional choices we have, many of which have been
convincingly associated with major health benefits related to brain and
cognitive health.
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